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- Academy of Music, c. 1857, Napoleon Le Brun, architect
- Boathouse Row, c. 1850s-1930s, various architects
- Carpenters' Hall, c. 1773, Robert Smith, designer; 320 Chestnut St.
- Church of the Advocate, c. 1887-1897, Charles M. Burns, Jr., architect; Diamond and 18th Streets
- Cliveden, c. 1764, the Benjamin Chew House; Germantown Avenue
- Colonial Germantown Historic District, founded by Francis Daniel Pastorius; Germantown Avenue
- Elfreth's Alley, c. 1702, purported to be the oldest, continuously-occupied residential street in America
- Fairmount Water Works, c. 1815, Benjamin Latrobe, architect; Schuylkill River near the Art Museum
- Furness Library, c. 1888, Frank Furness, architect; University of Penn Campus
- Mount Pleasant, c. 1762, Fairmount Park
- Pennsylvania Academy of the Fine Arts, c. 1882, Frank Furness, architect; 118 N. Broad St.
- Pennsylvania Hospital, c. 1756, Samuel Rhoads, architect; 800 Spruce St.
- Philadelphia Savings Fund Society [PSFS] Building, c. 1929, George Howe, architect; 1200 Market St.
- Second Bank of the United States, c. 1824, William Strickland, architect; 420 Chestnut St.
- Woodford, c. 1756; Fairmount Park (Dauphin St)
- American Philosophical Society Hall, c. 1789
- Athenaeum, c. 1847, Renaissance Revival, John Notman, architect; 219 S. 6th St.
- John Bartram House, c. 1731, 54th St.
- Becuna, c. 1944, Naval Submarine
- Christ Church, c. 1727-1754, 2nd Street at Market
- John Coltrane House, he lived here from 1952-1967; 1511 N. 3rd St.
- Edward Drinker Cope House, c. 1880, 2102 Pine St.
- Thomas Eakins House, c. 1820, Eakins home from 1846-1919; 1729 Mount Vernon Pl.
- Eastern State Penitentiary, c. 1857, John Haviland, architect; Fairmount Ave. and 21st St.
- First Bank of the United States, c. 1797, Samuel Blodgett, architect; 116 S. 3rd St.
- Old Fort Mifflin, c. 1772; Penrose Ferry Road
- Girard College, Founders Hall, c. 1832, Thomas U. Walter; Girard College Campus
- Friends Hospital, c. 1817; 4641 Roosevelt Blvd
- Germantown Cricket Club, c. 1889, McKim & Mead, architects
- Frances Ellen Watkins Harper House, c. before-1870, 1006 Bainbridge St
- Hill-Physick-Keith House, c. 1786; 321 S. 4th St.
- Institute of the Pennsylvania Hospital, c. 1859, 111 N. 49th Street
- Insurance Company of North America Building, c. 1925, Emlyn Stewardson & George Page, architects; 1600 Arch St.
- Johnson House, c. 1768; 6306 Germantown Ave.
- Laurel Hill Cemetery, c. 1836, John Notman, architect; 3822 Ridge Ave.
- J. Peter Lesley House, c. 1835; 1008 Clinton St. (part of Clinton Street Row, National Historic District)
- James Logan Home, (aka Stenton Mansion) c. 1728; 4601 N. 18th St.
- Memorial Hall, c. 1876, Hermann Schwartzmann, architect; Fairmount Park
- Mother Bethel A.M.E. Church, c. 1794, 1889; 419 S. 6th St.
- New Century Guild, c. 1850, Bunting & Shrigley, architects; 1307 Locust St.
- New Market, c. 1745, 1811; 419 S. Second St.
- U.S.S. Olympia, c. 1893, Historic Naval Cruiser
- Charles Wilson Peale House, c. 1750, 1810; 2100 Clarkson Ave.
- Philadelphia City Hall, c. 1871, 1881, John McArthur & Thomas U. Walter, architects; Broad & Market Sts.
- Philadelphia Contributorship, c. 1835, Thomas U. Walter, architect; 212 S. 4th St.
- Philadelphia School of Design for Women, (aka Edwin Forrest House) c. 1853,1865, Stephen D. Button, architect; 1326 N. Broad St.
- Philadelphia Masonic Temple, c. 1873, Joseph H. Windrin, architect; 1 N. Broad St.
- Edgar Allen Poe House, c. 1844; 530 N. 7th St.
- Race Street Friends Meeting House, c. 1856; 1518 Race St.
- Reading Terminal and Trainshed, c. 1893, Joseph Wilson, engineer; 1115 Market St.
- Reynolds-Morris House, c. 1787, John Reynolds, architect; 225 S, 8th St.
- Rittenhousetown Historic District, c. 1707; 206 Lincoln Dr., Fairmount Park
- Saint James the Less Episcopal Church, c. 1846; 3227 W. Clearfield St.
- Saint Mark's Episcopal Church, c. 1852, John Notman, architect; 1607 Locust St.
- Saint Peter's Protestant Episcopal Church, c. 1758, 1764, Robert Smith/William Strickland, architects; 313 Pine St.
- Thomas Sully Residence, c. 1820, 1860, 530 Spruce St.
- Henry O. Tanner Homesite, c. mid 19th century, 2908 W. Diamond St.
- United States Naval Asylum, c. 1827, 1844, William Strickland, architect; sold to Toll Brothers; restored as luxury condos; Grays Ferry Ave. at 24th St.
- Wagner Free Institute of Science, c. 1859, John McArthur, William Wagner, architects; 1700 Montgomery Ave.
- Walnut Street Theatre, c. 1809, 1828, John Haviland, architect; 825 Walnut St.
- John Wanamaker Store, c. 1875, 1904, D. Burnham & J. Windrim, architects; 1301 Chestnut Street
- Woodlands, c. 1770, 1790, (William Hamilton House); 4000 Woodland Ave.
- Wyck House, c. 1690; 6026 Germantown Ave.
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