The Saint Francois County Courthouse is located at 1 North Washington Street, Farmington, MO 63640. County administrative offices are located at 1 West Liberty Street, Farmington, MO 63640; phone: 573-756-5411.
Settlement in the region greatly increased with the Louisiana Purchase, and by 1821, the population had grown enough to warrant the creation of St. Francois County. St. Francois County, which was named after the St. Francois River, was organized from Jefferson, Ste. Genevieve, and Washington Counties. Farmington became the seat of the new county very soon after.